Drug Intermediate
Drug Iintermediate
Drug intermediates are used as raw materials for the production of bulk drugs, or they can refer to a material produced during synthesis of an API that must undergo further molecular change or processing before it becomes an API. Drug intermediates are hygienically formulated using high grade raw materials and they are used in the pharmaceutical and cosmetic industry[1][2].
References:
- [1]. Ma HC, et al. Homochiral Covalent Organic Framework for Catalytic Asymmetric Synthesis of a Drug Intermediate. J Am Chem Soc. 2020 Jul 22;142(29):12574-12578. [Content Brief]
- [2]. Ramachary D B, et al. Development of pharmaceutical drugs, drug intermediates and ingredients by using direct organo‐click reactions[J]. 2008.
All Product Categories
-
Drug Intermediate Related Products (4520)
Related Products (4520)
-
Glyoxal (40% w/w in water)
0 ImagesGlyoxal (40% w/w in water) is an α-oxoaldehyde that inhibits Aldose Reductase, Glutathione Reductase, and NADPH synthase. Glyoxal (40% w/w in water) exhibits cytotoxicity, triggers oxidative stress, induces ROS accumulation, lipid peroxidation, mitochondrial membrane potential collapse, DNA damage, apoptosis, and massive production of advanced glycation end products (AGEs). Glyoxal (40% w/w in water) depletes glutathione and activates MAPK phosphorylation. It has lower toxicity as a fixative than paraformaldehyde (PFA) and serves as a precursor for the synthesis of oxalates and dietary carcinogens. Glyoxal (40% w/w in water) is suitable for research related to calcium oxalate kidney stones, diabetes, atherosclerosis, cardiovascular diseases, retinopathy, and cataracts.
-
(2-Methoxypyrimidin-5-yl)boronic acid
0 Images(2-Methoxypyrimidin-5-yl)boronic acid is a drug intermediate that can serve as a key reactant in the Suzuki-Miyaura coupling reaction, and is used for the synthesis of isoquinoline ketone derivatives with anti-tumor activity.
-
L-Ribulose
0 ImagesCat. No.: HY-121305ACAS No.: 2042-27-5L-Ribulose is an L-form pentulose. L-Ribulose serves as a key precursor for the synthesis of L-ribose and L-nucleoside analogs.
-
Cycloheptane-1,3-dione
0 ImagesCycloheptane-1,3-dione (Compound 1A) is an intermediate. Cycloheptane-1,3-dione can be used to synthesize Compound 1-1. Compound 1-1 has anticancer activity against colon cancer.
-
2,3,4,6-Tetra-O-benzyl-D-glucopyranose
0 ImagesCat. No.: HY-W010751CAS No.: 4132-28-9Synonyms: 2,3,4,6-Tetrakis-O-(phenylmethyl)-D-glucopyranose2,3,4,6-Tetra-O-benzyl-D-glucopyranose is a glucose derivative that serves as an important intermediate in the synthesis of complex glycoconjugates, oligosaccharides, and glycosylated drug molecules.
-
1,3-Oxazolidine-2-thione
0 Images1,3-Oxazolidine-2-thione, a free oxazolidinethione, increases thyroid size and severely depresses hepatic trimethylamine oxidase activity in the brown-egg layers.
-
2-Bromoisonicotinic acid
0 Images2-Bromoisonicotinic acid is a (hetero)aryl bromide building block and DNA-conjugated headpiece for photochemical C-H heteroarylation in DNA-encoded library synthesis. 2-Bromoisonicotinic acid generates a nucleophilic pyridyl radical intermediate. 2-Bromoisonicotinic acid, when conjugated to DNA, leaves electrophilic handles intact for subsequent library diversification.
-
4,4'-Dihydroxybenzophenone
0 Images4,4'-Dihydroxybenzophenone is a type of phenolic ultraviolet absorber and a drug intermediate for synthesis of various anticancer active compounds (such as Sivifene (HY-14801)). 4,4'-Dihydroxybenzophenone binds to the active site of trypsin with binding constants (KA = 7.59 x 105 L/moL) and leads to abnormal structure of trypsin, suggesting that long-term intake may affect the digestive function of the human body. 4,4’-dihydroxybenzophenone has a relatively low toxicity to Chlorella vulgaris and a moderate toxicity to Daphnia magna.
-
4-Nitropyrazole
0 Images4-Nitropyrazole is a five-membered nitrogen-containing heterocyclic compound that can be used as a drug intermediate. 4-Nitropyrazole can be synthesized into antibiotics/antifungal/antiviral agents containing pyrazole rings. 4-Nitropyrazole is synthesized through C-H activation reactions to produce LRRK2 inhibitors, which are used in the research of Parkinson's disease.
-
2-Amino-4-chloropyridine
0 Images2-Amino-4-chloropyridine is a key intermediate. 2-Amino-4-chloropyridine derivatives exhibit antibacterial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi.
-
Perylene-3,4,9,10-tetracarboxylic acid
0 ImagesCat. No.: HY-W106762CAS No.: 81-32-3Synonyms: 3,4,9,10-Perylenetetracarboxylic acidPerylene-3,4,9,10-tetracarboxylic acid (3,4,9,10-Perylenetetracarboxylic acid) is a chemical intermediate. Derivatives formed from Perylene-3,4,9,10-tetracarboxylic acid can serve as colorimetric and fluorescent chemosensors with selectivity for fluoride ions, and also act as charge generation materials in electrophotographic photoreceptors, organic electrophotographic photoreceptors, optoelectronic and photonic devices.
-
5-Bromo-2-fluoro-3-methylpyridine
0 ImagesCat. No.: HY-32757CAS No.: 29312-98-9Synonyms: 5-Bromo-2-fluoro-3-picoline5-Bromo-2-fluoro-3-methylpyridine (5-Bromo-2-fluoro-3-picoline) is a drug synthesis intermediate that can be used to synthesize an inhibitor of dihydroorotate dehydrogenase (DHODH).
